1285 PLACENTAL DEVELOPMENT IN THE TRISOMY 16 MOUSE
نویسندگان
چکیده
منابع مشابه
Mitochondrial dysfunction in mouse trisomy 16 brain.
Mitochondrial function in the brain of mouse trisomy 16, an animal model of Down syndrome with accelerated neuron death, was studied in isolated cortex mitochondria. Using an oxygen-sensitive Clarke electrode, a selective 16% decrease in respiration was detected with the Complex I substrates malate and glutamate but not with the Complex II substrate succinate. Western blotting revealed a 20% de...
متن کاملTetrasomy 16 in the mouse: a more severe condition than the corresponding trisomy.
Although an understanding of the phenotypic similarities and differences between individuals trisomic and tetrasomic for the same chromosome or chromosome segment is of considerable theoretical interest with regard to the relationship of the phenotypic features of aneuploid states to changes in the dosage of specific genes, the data obtainable from human cases of tetrasomy do not permit firm co...
متن کاملDefects in Thymocyte Differentiation and Thymocyte- Stromal Interactions in the Trisomy 16 Mouse
We have examined fetal thymic development in the trisomy 16 (Ts16) mouse, which is considered to be a model for human trisomy 21, or Down Syndrome. The Ts16 thymus contains 10 to 20% of the number of lymphocytes found in a normal thymus at a comparable stage. Expression of thymocyte differentiation markers (Thy-1, CD5, CD8, CD4, CD3, and HSA) is severely affected in Ts16 fetuses aged 14-18 gest...
متن کاملRole of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.
Development of the neocortex of the trisomy 16 (Ts16) mouse, an animal model of Down syndrome (DS), is characterized by a transient delay in the radial expansion of the cortical wall and a persistent reduction in cortical volume. Here we show that at each cell cycle during neuronogenesis, a smaller proportion of Ts16 progenitors exit the cell cycle than do control, euploid progenitors. In addit...
متن کاملMechanisms of deficient cardiac septation in the mouse with trisomy 16.
It used to be thought that the atrioventricular septum was predominantly the product of the atrioventricular endocardial cushions. In a previous study, we have shown that multiple developmental primordia are of importance in its formation. With this in mind, we have evaluated cardiac morphogenesis in the mouse with trisomy 16, an animal model with a high incidence of atrioventricular septal def...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198504000-01309